Glucose loading for heart failure protects the myocardium and improves physical function

Ryoichi Nishida; Jun Goto; Noboru Kamajiri; Shogo Terayama; Mimo Shirahase; Hidetaka Imagita

doi:10.1589/jpts.35.542

Glucose loading for heart failure protects the myocardium and improves physical function

J Phys Ther Sci. 2023 Jul;35(7):542-546. doi: 10.1589/jpts.35.542. Epub 2023 Jul 1.

Authors

Ryoichi Nishida^{1

2}, Jun Goto³, Noboru Kamajiri⁴, Shogo Terayama⁵, Mimo Shirahase⁴, Hidetaka Imagita⁶

Affiliations

¹ Takanohara Central Hospital: 1-3-3 Ukyo, Nara-shi, Nara 631-0805, Japan.
² Department of Molecular Pathology, Nara Medical University, Japan.
³ Department of Anatomy and Cell Biology, Graduate School of Medicine, Osaka Metropolitan University, Japan.
⁴ Kishiwada Rehabilitation Hospital, Japan.
⁵ Department of Physical Therapy, Faculty of Health Science, Kio University, Japan.
⁶ Department of Physical Therapy, Health and Social Services, Saitama Prefectural University, Japan.

Abstract

[Purpose] The purpose of this study was to investigate the effects of glucose intake on physical function in a heart failure rat model. [Materials and Methods] Five-week-old male Wistar rats were used for this study. Monocrotalin (40 mg/kg) was administered intraperitoneally to rats to induce heart failure. The rats were divided into two groups, control and MCT; the MCT group was further classified according to glucose concentration (0%, 10%, and 50%). [Results] Glucose intake during heart failure prevented the loss of body weight, skeletal muscle, and fat mass. Myocardial metabolism in heart failure was enhanced by hypoxia, which in turn, enhanced the glycolytic system. [Conclusion] Glucose loading suppressed cardiac hypertrophy and improved physical function in the heart failure rat model.

Keywords: Cardiac cachexia; Heart failure; Myocardium metabolism.