Function of TRP channels in monocytes/macrophages

Jiangbo Wu; Zhuo Li; Ya Deng; Xianmin Lu; Chen Luo; Xingyi Mu; Ting Zhang; Qi Liu; Siqi Tang; Jiajing Li; Qimin An; Dongdong Fan; Yiwei Xiang; Xianli Wu; Yanxia Hu; Qian Du; Jingyu Xu; Rui Xie

doi:10.3389/fimmu.2023.1187890

Function of TRP channels in monocytes/macrophages

Front Immunol. 2023 Jun 19:14:1187890. doi: 10.3389/fimmu.2023.1187890. eCollection 2023.

Authors

Jiangbo Wu^{1

2}, Zhuo Li^{1

2}, Ya Deng^{1

2}, Xianmin Lu^{1

2}, Chen Luo^{1

2}, Xingyi Mu^{1

2}, Ting Zhang^{1

2}, Qi Liu^{1

2}, Siqi Tang^{1

2}, Jiajing Li^{1

2}, Qimin An^{1

2}, Dongdong Fan^{1

2}, Yiwei Xiang^{1

2}, Xianli Wu^{1

2}, Yanxia Hu^{1

2}, Qian Du^{1

2}, Jingyu Xu¹, Rui Xie¹

Affiliations

¹ Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
² The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, China.

Abstract

The transient receptor potential channel (TRP channel) family is a kind of non- specific cation channel widely distributed in various tissues and organs of the human body, including the respiratory system, cardiovascular system, immune system, etc. It has been reported that various TRP channels are expressed in mammalian macrophages. TRP channels may be involved in various signaling pathways in the development of various systemic diseases through changes in intracellular concentrations of cations such as calcium and magnesium. These TRP channels may also intermingle with macrophage activation signals to jointly regulate the occurrence and development of diseases. Here, we summarize recent findings on the expression and function of TRP channels in macrophages and discuss their role as modulators of macrophage activation and function. As research on TRP channels in health and disease progresses, it is anticipated that positive or negative modulators of TRP channels for treating specific diseases may be promising therapeutic options for the prevention and/or treatment of disease.

Keywords: TRP channels; macrophage; macrophage polarization; monocytes; system disease.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Macrophages
Mammals / metabolism
Monocytes*
Transient Receptor Potential Channels* / metabolism

Substances

Transient Receptor Potential Channels

Grants and funding

This study was supported by research grants the National Natural Science Foundation of China (No.81660099; No. 82170628; No.81970541; No.31960151; No.32160208; No.81770610) and Collaborative Innovation Center of Chinese Ministry of Education (2020-39); Guizhou Science and Technology Department (Qiankehe platform talents (2021-5647)); Zunyi Science and Technology Bureau (Outstanding Young Talents in Zunyi City (2018-9;2020-1)); Guizhou Science and Technology Department (Qiankehe foundation-ZK (2021–major project 004); and Graduate Education and Teaching Innovation Program of Zunyi Medical University (ZYK163).