Verbalide A~F: new phthalide derivatives from the endophytic fungus Preussia sp. CPCC 400972

Ran Zhang; Yujia Wang; Guowei Cai; Juxian Wang; Jianyuan Zhao; Jinglin Bai; Tao Zhang; Shan Cen; Wenni He; Liyan Yu

doi:10.1038/s41429-023-00640-z

Verbalide A~F: new phthalide derivatives from the endophytic fungus Preussia sp. CPCC 400972

J Antibiot (Tokyo). 2023 Oct;76(10):613-617. doi: 10.1038/s41429-023-00640-z. Epub 2023 Jul 4.

Authors

Ran Zhang¹, Yujia Wang^{2

3}, Guowei Cai¹, Juxian Wang¹, Jianyuan Zhao^{2

3}, Jinglin Bai^{1

3}, Tao Zhang^{1

3}, Shan Cen^{2

3}, Wenni He⁴, Liyan Yu^{5

6}

Affiliations

¹ China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
² Immunology Division, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
³ Division for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing, 100050, China.
⁴ China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. winner0047@163.com.
⁵ China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. yly@cpcc.ac.cn.
⁶ Division for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing, 100050, China. yly@cpcc.ac.cn.

PMID: 37402885
DOI: 10.1038/s41429-023-00640-z

Abstract

There are six new phthalide derivatives Verbalide A ~ F (1-6) together with another known derivative (7) isolated from the endophytic fungus Preussia sp. CPCC 400972. Their structures were established by comprehensive spectroscopic analyses, including NMR and HRESIMS. In addition, compounds 1-7 exhibited excellent inhibitory effect against influenza A virus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ascomycota* / chemistry
Benzofurans* / chemistry
Benzofurans* / pharmacology
Magnetic Resonance Spectroscopy
Molecular Structure

Substances

phthalide
Benzofurans