[Insufficient elevation of TSH before therapy with I131 in a patient with metastatic differentiated thyroid carcinoma]

Rev Fac Cien Med Univ Nac Cordoba. 2023 Jun 30;80(2):149-152. doi: 10.31053/1853.0605.v80.n2.38112.
[Article in Spanish]

Abstract

Guidelines suggest a thyrotropin (TSH) stimulation level ≥30 mIU/l for the administration of 131-iodine (I131) in patients with differentiated thyroid carcinoma (DTC). We present a patient with follicular thyroid carcinoma (FTC), with spinal metastasis as the initial manifestation, who after 6 weeks without levothyroxine did not present an elevation of ≥30 mIU/l of TSH. This situation was interpreted as secondary to the presence of functioning metastases and it was decided, regardless of the TSH level, to administer a therapeutic dose of I131, with iodine-uptake lesions in the liver and spine being confirmed.

Las guías sugieren un nivel de estimulación de tirotrofina (TSH) ≥30 mUI/l para la administración de yodo 131 (I131) en pacientes con carcinoma diferenciado de tiroides (CDT). Presentamos una paciente con carcinoma folicular de tiroides (CFT), con metástasis vertebral como manifestación inicial, que tras 6 semanas sin levotiroxina no presentó una elevación ≥30 mUI/l de TSH. Esta situación fue interpretada como secundaria a la presencia de metástasis funcionantes y se decidió, independientemente del valor de TSH, la administración de una dosis terapéutica de I131 constatándose lesiones captantes de I131 en hígado y columna vertebral.

Keywords: thyroid neoplasms; thyrotropine; iodine.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Humans
  • Iodine* / therapeutic use
  • Thyroid Neoplasms* / drug therapy
  • Thyroid Neoplasms* / pathology
  • Thyrotropin / therapeutic use
  • Thyroxine / therapeutic use

Substances

  • Thyroxine
  • Thyrotropin
  • Iodine