Collagen architecture and signaling orchestrate cancer development

Hua Su; Michael Karin

doi:10.1016/j.trecan.2023.06.002

Collagen architecture and signaling orchestrate cancer development

Trends Cancer. 2023 Sep;9(9):764-773. doi: 10.1016/j.trecan.2023.06.002. Epub 2023 Jul 1.

Authors

Hua Su¹, Michael Karin²

Affiliations

¹ Institutes of Biomedical Sciences, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: suhua@fudan.edu.cn.
² Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address: karinoffice@health.ucsd.edu.

PMID: 37400314
DOI: 10.1016/j.trecan.2023.06.002

Abstract

The tumor microenvironment (TME) controls tumor progression and maintenance. Accordingly, tumor-centric cancer treatment must adjust to being more holistic and TME-centric. Collagens are the most abundant TME proteins, and their dynamic remodeling profoundly affects both TME architecture and tumor development. Recent evidence shows that in addition to being structural elements, collagens are an important source of nutrients and decisive growth controlling and immunoregulatory signals. This review focuses on macropinocytosis-dependent collagen support of cancer cell metabolism and the role of collagen fiber remodeling and trimer heterogeneity in control of tumor bioenergetics, growth, progression, and response to therapy. If properly translated, these basic advances may alter the future of cancer treatment.

Keywords: DDR1; LAIR1; collagen; immunity; macropinocytosis; tumor microenvironment.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Collagen / metabolism
Humans
Neoplasms* / pathology
Signal Transduction
Tumor Microenvironment

Substances

Collagen

Abstract

Publication types

MeSH terms

Substances

Grants and funding