Atypical hyperplasia of the breast: Clinical cases and management strategies

Suneela Vegunta; Dawn M Mussallem; Aparna S Kaur; Sandhya Pruthi; Christine L Klassen

doi:10.3949/ccjm.90a.22098

Atypical hyperplasia of the breast: Clinical cases and management strategies

Cleve Clin J Med. 2023 Jul 3;90(7):423-431. doi: 10.3949/ccjm.90a.22098.

Authors

Suneela Vegunta¹, Dawn M Mussallem², Aparna S Kaur³, Sandhya Pruthi⁴, Christine L Klassen⁵

Affiliations

¹ Assistant Professor of Medicine; Vice-Chair, Division of Women's Health Internal Medicine, Mayo Clinic, Scottsdale, AZ vegunta.suneela@mayo.edu.
² Assistant Professor of Medicine; Consultant, Breast Diagnostic Clinic, Jacoby Center for Breast Health, Mayo Clinic, Jacksonville, FL.
³ Assistant Professor of Medicine; Consultant, Breast Diagnostic Clinic, Mayo Clinic, Rochester, MN.
⁴ Professor of Medicine; Consultant, Breast Diagnostic Clinic, Mayo Clinic, Rochester, MN.
⁵ Assistant Professor of Medicine; Director, Breast Diagnostic Clinic, Mayo Clinic, Rochester, MN.

PMID: 37400158
DOI: 10.3949/ccjm.90a.22098

Abstract

Atypical hyperplasia of the breast is a histopathologic lesion identified incidentally on image-guided breast biopsy. It is associated with a substantial increase in lifetime risk for breast cancer. Clinicians should counsel women with atypical hyperplasia regarding risk-reducing strategies, which include preventive endocrine therapy options, enhanced surveillance imaging, and lifestyle modifications. In this review, we describe 5 different but common clinical case scenarios for atypical hyperplasia of the breast and review management strategies for each scenario.

Publication types

Review

MeSH terms

Breast Neoplasms* / diagnosis
Breast Neoplasms* / therapy
Breast* / diagnostic imaging
Diagnostic Imaging
Female
Humans
Hyperplasia / pathology