The role of TGF-β in the tumor microenvironment of pancreatic cancer

Qiang Luo; Ziquan Hu; Hongcheng Zhao; Yanmei Fan; Xiancong Tu; Yueqing Wang; Xiaowen Liu

doi:10.1016/j.gendis.2022.10.019

The role of TGF-β in the tumor microenvironment of pancreatic cancer

Genes Dis. 2022 Nov 19;10(4):1513-1524. doi: 10.1016/j.gendis.2022.10.019. eCollection 2023 Jul.

Authors

Qiang Luo¹, Ziquan Hu¹, Hongcheng Zhao¹, Yanmei Fan¹, Xiancong Tu¹, Yueqing Wang¹, Xiaowen Liu¹

Affiliation

¹ Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang, Hubei 443003, China.

Abstract

Pancreatic cancer (PC) is an aggressive malignant tumor with low rate of surgical resection and poor prognosis. Transforming growth factor-β (TGF-β) is a cytokine that has both protumor and antitumor activities, depending on tumor microenvironment. The interaction between TGF-β signaling and the tumor microenvironment in PC is complex. Here, we reviewed the role of TGF-β in the tumor microenvironment of PC, highlighting producers of TGF-β and TGF-β responders in the tumor microenvironment of PC.

Keywords: Cancer therapy; Pancreatic cancer; Smad 4; Transforming growth factor-β; Tumor microenvironment.

Publication types

Review