YAP at the progression of inflammation

Libin Chen; Xintong Jin; Jian Ma; Bo Xiang; Xiayu Li

doi:10.3389/fcell.2023.1204033

YAP at the progression of inflammation

Front Cell Dev Biol. 2023 Jun 15:11:1204033. doi: 10.3389/fcell.2023.1204033. eCollection 2023.

Authors

Libin Chen^{1

2}, Xintong Jin^{1

2}, Jian Ma^{3

2}, Bo Xiang^{3

2}, Xiayu Li^{1

2}

Affiliations

¹ Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China.
² Hunan Key Laboratory of Nonresolving Inflammation and Cancer, The Third Xiangya Hospital of Central South University, Changsha, China.
³ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Sciences, Central South University, Changsha, China.

Abstract

Yes-associated protein (YAP) is a transcriptional regulator that affects cell proliferation, organ size and tissue development and regeneration, and has therefore, been an important object of study. In recent years, there has been an increasing research focus on YAP in inflammation and immunology, and the role of YAP in the development of inflammation and in immune escape by tumors has been progressively elucidated. Because YAP signaling involves a variety of different signal transduction cascades, the full range of functions in diverse cells and microenvironments remains incompletely understood. In this article, we discuss the complex involvement of YAP in inflammation, the molecular mechanisms through which it exercises pro- and anti-inflammatory effects under different conditions, and the progress achieved in elucidating the functions of YAP in inflammatory diseases. A thorough understanding of YAP signaling in inflammation will provide a foundation for its use as a therapeutic target in inflammatory diseases.

Keywords: IFN-I; NF-κB; YAP; inflammation; inflammatory disease; macrophages.

Publication types

Review

Grants and funding

This work was supported in part by grants from The National Natural Science Foundation of China (82172766, 82073261), the Natural Science Foundation of Hunan Province, China (2020JJ4838), the Scientific Research Project of Hunan Provincial Health Commission (20201040).