Pathophysiological Link Between Chronic Rhinosinusitis and Ear Disease

Curr Allergy Asthma Rep. 2023 Jul;23(7):389-397. doi: 10.1007/s11882-023-01072-3. Epub 2023 Jul 3.

Abstract

Purpose of review: In the clinical practice, patients affected by chronic rhinosinusitis (CRS) commonly complain of otologic symptoms. This review aims to describe the available literature evidence assessing the relationship between CRS and ear illnesses published in the last 5 years.

Recent findings: Available evidence suggests a higher prevalence of otologic symptoms in patients suffering from CRS, affecting up to 87% of patients. These symptoms may be related to Eustachian tube dysfunction, which improves after treatment for CRS. A few studies suggested a potential but not confirmed role of CRS in cholesteatoma, chronic otitis media, and sensorineural hypoacusis. A special type of otitis media with effusion (OME) may occur in patients with CRS, which seems to respond well to new biologic therapy. Ear symptoms appear to be highly prevalent in patients with CRS. So far, the available evidence is robust only for Eustachian tube dysfunction, which has been shown to be particularly impaired in CRS patients. Additionally, the Eustachian tube function appears to improve after treatment for CRS. Finally, interesting preliminary data were described for eosinophilic otitis media, as it appears to respond well to the treatment with biologics.

Keywords: CRSwNP; Cholesteatoma; Chronic otitis media; Chronic rhinosinusitis (CRS); Eosinophilic otitis; Hearing loss; Monoclonal antibodies.

Publication types

  • Review

MeSH terms

  • Chronic Disease
  • Ear Diseases* / complications
  • Ear Diseases* / epidemiology
  • Eustachian Tube*
  • Humans
  • Otitis Media with Effusion* / complications
  • Otitis Media with Effusion* / epidemiology
  • Otitis Media*
  • Sinusitis* / complications
  • Sinusitis* / epidemiology