The Role of Oxidative Stress in the Induction and Development of Psoriasis

Front Biosci (Landmark Ed). 2023 Jun 25;28(6):118. doi: 10.31083/j.fbl2806118.

Abstract

Psoriasis cannot be completely cured and is often difficult to diagnose, which is why the search for new effective therapies and diagnostics is a highly relevant area of research. To identify new therapeutic compounds, the first step is to study the role of various factors underlying the development of psoriasis. One such factor is oxidative stress. In this review, we will consider the role of oxidative stress at different stages of psoriasis development, as well as biomarkers of oxidative stress that can potentially be used in the diagnosis of psoriasis and antioxidants, which are likely to be applied in the treatment of this disease.

Keywords: oxidative stress; psoriasis; skin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antioxidants / therapeutic use
  • Autoimmune Diseases / complications
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / metabolism
  • Autoimmune Diseases / pathology
  • Biomarkers / metabolism
  • Disease Progression*
  • Humans
  • Inflammation / complications
  • Inflammation / immunology
  • Inflammation / metabolism
  • Inflammation / pathology
  • Keratinocytes / metabolism
  • Keratinocytes / pathology
  • Oxidative Stress*
  • Psoriasis* / complications
  • Psoriasis* / drug therapy
  • Psoriasis* / immunology
  • Psoriasis* / metabolism
  • Reactive Oxygen Species / metabolism

Substances

  • Antioxidants
  • Reactive Oxygen Species
  • Biomarkers