Our view of amyloidosis has changed deeply over the last 10 years following major advances in diagnosis and treatment options, especially in cardiac amyloidosis. This intrinsically heterogeneous disease requires the interaction among experts of different specialties and subspecialties. Suspicion of disease, timely recognition and confirmation of final diagnosis, prognostic stratification, clinical management and therapeutic strategies represent essential steps to be taken. The Italian Network for Cardiac Amyloidosis is able to deal with the challenges of this condition and orient clinical management of patients at either national or local level. The present review article aims to provide potential research questions on cardiac amyloidosis that have not been investigated yet and that the Italian Network might explore in the near future.