During the Covid-19 pandemic, territorial services and general practitioners in particular played a central role in identifying suspected cases and contact tracing. Vulnerability criteria were defined to identify patients at risk of developing severe forms of infection, which were later used to direct patients towards appropriate mitigation measures and prioritize access to vaccinations. The identification of individuals at risk of severe Covid-19 remains crucial, especially for particularly vulnerable patients with oncohematological and cardiovascular conditions, who require specific preventive and therapeutic strategies.