Cases of Yolk sac tumor associated with gynecological malignant tumor

Shengchao Wang; Kelie Chen; Qin Chen; Shuai Huang; Weiguo Lu

doi:10.1186/s12905-023-02495-w

Cases of Yolk sac tumor associated with gynecological malignant tumor

BMC Womens Health. 2023 Jun 30;23(1):348. doi: 10.1186/s12905-023-02495-w.

Authors

Shengchao Wang^#¹, Kelie Chen^#¹, Qin Chen¹, Shuai Huang¹, Weiguo Lu²

Affiliations

¹ Department of Gynecological Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China.
² Department of Gynecological Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China. lbwg@zju.edu.cn.

^# Contributed equally.

Abstract

Background: Yolk sac tumour (YST) is the second most common ovarian germ cell tumour and usually presents in children and young women. However, tumours rarely occur as malignant gynaecological tumours with YST components.

Case presentation: We present one case of endometrioid carcinoma and clear cell carcinoma with YST components and two other cases of YSTs associated with high-grade serous carcinoma of the ovary in females. After surgery and adjuvant chemotherapy, the patient with endometrioid carcinoma had progressive disease and died 20 months later, and the other two were still alive at the last follow-up.

Conclusions: To our knowledge, these mixed neoplasm associations are unusual, and these cases illustrate the diagnosis and prognosis of YST associated with malignant gynaecological tumours, emphasizing early recognition and aggressive treatment.

Keywords: Chemotherapy; Malignant gynaecological tumours; Prognosis; Treatment; Yolk sac tumour (YST).

Publication types

Case Reports

MeSH terms

Adenocarcinoma, Clear Cell*
Carcinoma, Endometrioid* / complications
Endodermal Sinus Tumor* / complications
Female
Genital Neoplasms, Female*
Humans
Ovarian Neoplasms* / complications