Prevalence of Mycobacterium tuberculosis mutations associated with isoniazid and rifampicin resistance: A systematic review and meta-analysis

Mosayeb Rostamian; Sara Kooti; Ramin Abiri; Saeed Khazayel; Sepide Kadivarian; Soroush Borji; Amirhooshang Alvandi

doi:10.1016/j.jctube.2023.100379

Prevalence of Mycobacterium tuberculosis mutations associated with isoniazid and rifampicin resistance: A systematic review and meta-analysis

J Clin Tuberc Other Mycobact Dis. 2023 Jun 1:32:100379. doi: 10.1016/j.jctube.2023.100379. eCollection 2023 Aug.

Authors

Mosayeb Rostamian¹, Sara Kooti², Ramin Abiri³, Saeed Khazayel⁴, Sepide Kadivarian⁵, Soroush Borji⁵, Amirhooshang Alvandi⁶

Affiliations

¹ Infectious Diseases Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
² Behbahan Faculty of Medical Sciences, Behbahan, Iran.
³ Fertility and Infertility Research Center, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
⁴ Deupty of Research and Technology Kermanshah University of Medical Sciences, Kermanshah, Iran.
⁵ Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
⁶ Medical Technology Research Center, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Abstract

Tuberculosis (TB) is still one of the leading causes of worldwide death, especially following the emergence of strains resistant to isoniazid (INH) and rifampicin (RIF). This study aimed to systematically review published articles focusing on the prevalence of INH and/or RIF resistance-associated mutations of Mycobacterium tuberculosis isolates in recent years. Literature databases were searched using appropriate keywords. The data of the included studies were extracted and used for a random-effects model meta-analysis. Of the initial 1442 studies, 29 were finally eligible to be included in the review. The overall resistance to INH and RIF was about 17.2% and 7.3%, respectively. There was no difference between the frequency of INH and RIF resistance using different phenotypic or genotypic methods. The INH and/or RIF resistance was higher in Asia. The S315T mutation in KatG (23.7 %), C-15 T in InhA (10.7 %), and S531L in RpoB (13.5 %) were the most prevalent mutations. Altogether, the results showed that due to S531L in RpoB, S315T in KatG, and C-15 T in InhA mutations INH- and RIF-resistant M. tuberculosis isolates were widely distributed. Thus, it would be diagnostically and epidemiologically beneficial to track these gene mutations among resistant isolates.

Keywords: Antibiotic resistance; Isoniazid; Mutation; Mycobacterium tuberculosis; Rifampicin.