Amamine, an isoquinoline alkaloid from the Kitasatospora sp. HGTA304

Teppei Kawahara; Marin Ueda; Naoki Kishimoto; Tae Yasutake; Shogo Misumi; Hari Prasad Devkota; Mikiyo Wada

doi:10.1038/s41429-023-00641-y

Amamine, an isoquinoline alkaloid from the Kitasatospora sp. HGTA304

J Antibiot (Tokyo). 2023 Oct;76(10):623-625. doi: 10.1038/s41429-023-00641-y. Epub 2023 Jun 29.

Authors

Teppei Kawahara¹, Marin Ueda², Naoki Kishimoto², Tae Yasutake², Shogo Misumi², Hari Prasad Devkota², Mikiyo Wada²

Affiliations

¹ Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan. teppei@kumamoto-u.ac.jp.
² Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.

PMID: 37386154
DOI: 10.1038/s41429-023-00641-y

Abstract

Amamine (1), a new isoquinoline alkaloid, was isolated from the culture extract of an actinomycete Kitasatospora sp. HGTA304. The structure of 1 was determined by NMR and MS analyses in combination with UV data. Compound 1 displayed α-glucosidase inhibitory potential (IC₅₀ value of 56 μM) compared with acarbose (IC₅₀ value of 549 μM) as standard.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids* / pharmacology
Antineoplastic Agents*
Glycoside Hydrolase Inhibitors / chemistry
Glycoside Hydrolase Inhibitors / pharmacology
Isoquinolines / pharmacology
Magnetic Resonance Spectroscopy
Molecular Structure
Streptomycetaceae*

Substances

Glycoside Hydrolase Inhibitors
Alkaloids
Antineoplastic Agents
Isoquinolines