Three players in the 'toxic affair' between botulinum neurotoxin type A and neurons

Ornella Rossetto; Marco Pirazzini; Cesare Montecucco

doi:10.1016/j.tins.2023.06.001

Three players in the 'toxic affair' between botulinum neurotoxin type A and neurons

Trends Neurosci. 2023 Sep;46(9):695-697. doi: 10.1016/j.tins.2023.06.001. Epub 2023 Jun 27.

Authors

Ornella Rossetto¹, Marco Pirazzini², Cesare Montecucco³

Affiliations

¹ Department of Biomedical Sciences, University of Padova, Padova, Italy; Consiglio Nazionale delle Ricerche, Institute of Neuroscience, University of Padova, Padova, Italy. Electronic address: ornella.rossetto@unipd.it.
² Department of Biomedical Sciences, University of Padova, Padova, Italy.
³ Department of Biomedical Sciences, University of Padova, Padova, Italy; Consiglio Nazionale delle Ricerche, Institute of Neuroscience, University of Padova, Padova, Italy.

PMID: 37385877
DOI: 10.1016/j.tins.2023.06.001

Abstract

Joensuu and colleagues have recently shown that botulinum neurotoxin (BoNT) type A exploits a heterotrimeric complex in the presynaptic membrane to bind to and enter neurons using a Trojan horse-like mechanism. Similar processes may be relevant to the neuronal entry of different botulinum toxin serotypes and other neuropathogens.

Keywords: SV2; botulinum toxin type A; endocytosis; polysialoganglioside; synaptic vesicle; synaptotagmin-1.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Botulinum Toxins, Type A* / metabolism
Membrane Glycoproteins / metabolism
Nerve Tissue Proteins / metabolism
Neurons / metabolism
Synaptic Vesicles / metabolism

Substances

Botulinum Toxins, Type A
Membrane Glycoproteins
Nerve Tissue Proteins