The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation

Charles L Limoli; Eniko A Kramár; Aymeric Almeida; Benoit Petit; Veljko Grilj; Janet E Baulch; Paola Ballesteros-Zebadua; Billy W Loo Jr; Marcelo A Wood; Marie-Catherine Vozenin

doi:10.1016/j.radonc.2023.109767

The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation

Radiother Oncol. 2023 Sep:186:109767. doi: 10.1016/j.radonc.2023.109767. Epub 2023 Jun 28.

Affiliations

¹ Department of Radiation Oncology, University of California, Irvine, CA 92697-2695, USA. Electronic address: climoli@uci.edu.
² Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
³ Laboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland.
⁴ Department of Radiation Oncology, University of California, Irvine, CA 92697-2695, USA.
⁵ Laboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland; Laboratorio de Fisica Medica, Instituto Nacional de Neurología y Neurocirugía MVS, México City 14269, Mexico.
⁶ Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁷ Laboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland. Electronic address: marie-catherine.vozenin@chuv.ch.

Abstract

Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 Gy (30 Gy total) conventional radiotherapy. Remarkably, 10x3Gy FLASH radiotherapy and unirradiated controls were identical and exhibited normal LTP.

Keywords: FLASH radiotherapy; Long-term potentiation; Standard-of care fractionation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Hippocampus / physiology
Long-Term Potentiation* / physiology
Mice
Neuronal Plasticity* / physiology
Synaptic Transmission / physiology

The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation

Authors

Affiliations

Abstract

Publication types

MeSH terms

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