Growing thin - How bulk lipid transport drives expansion of the autophagosome membrane but not of its lumen

Abstract

The key event in macroautophagy is the de novo formation of a new organelle called the autophagosome which when complete, will have captured bits of cytoplasm within its double-membrane structure. Eventual fusion with the lysosome allows this captured material to be degraded back to simple molecules which can be recycled to support cell function during starvation. How autophagosomes form has been a challenging question for over 60 years. This review highlights work that forms the basis for an autophagosome membrane expansion model grounded in protein-mediated lipid transport.