Langmuir-Blodgett-Mediated Formation of Antibacterial Microneedles for Long-Term Transdermal Drug Delivery

Ziyi Lu; Shan Du; Jiaxun Li; Min Zhang; Huali Nie; Xiaojun Zhou; Fulun Li; Xinwei Wei; Jinqiang Wang; Fuyao Liu; Chuanglong He; Guang Yang; Zhen Gu

doi:10.1002/adma.202303388

Langmuir-Blodgett-Mediated Formation of Antibacterial Microneedles for Long-Term Transdermal Drug Delivery

Adv Mater. 2023 Sep;35(38):e2303388. doi: 10.1002/adma.202303388. Epub 2023 Jul 27.

Authors

Ziyi Lu¹, Shan Du¹, Jiaxun Li², Min Zhang³, Huali Nie¹, Xiaojun Zhou¹, Fulun Li⁴, Xinwei Wei⁵, Jinqiang Wang⁵, Fuyao Liu⁵, Chuanglong He¹, Guang Yang^{1

6}, Zhen Gu^{5

7

8

9

10

11}

Affiliations

¹ Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.
² College of Basic Medicine, Naval Medical University, Shanghai, 200433, China.
³ College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China.
⁴ Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
⁵ Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
⁶ State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200438, China.
⁷ Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.
⁸ Jinhua Institute of Zhejiang University, Jinhua, 321299, China.
⁹ Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, China.
¹⁰ National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou, 310058, China.
¹¹ MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.

PMID: 37384857
DOI: 10.1002/adma.202303388

Abstract

Microneedles (MNs) have become versatile platforms for minimally invasive transdermal drug delivery devices. However, there are concerns about MN-induced skin infections with long-term transdermal administration. Using the Langmuir-Blodgett (LB) technique, a simple method for depositing antibacterial nanoparticles of various shapes, sizes, and compositions onto MNs is developed. This strategy has merits over conventional dip coating techniques, including controlled coating layers, uniform and high coverage, and a straightforward fabrication process. This provides MNs with a fast-acting and long-lasting antibacterial effect. This study demonstrates that antibacterial MNs achieve superior bacterial elimination in vitro and in vivo without sacrificing payload capacity, drug release, or mechanical strength. It is believed that such a functional nanoparticle coating technique offers a platform for the expansion of MNs function, especially in long-term transdermal drug delivery fields.

Keywords: antibacterial nanoparticles; langmuir-Blodgett coating technique; microneedles; nanomedicine; skin infection; transdermal drug delivery.

MeSH terms

Administration, Cutaneous
Anti-Bacterial Agents / pharmacology
Drug Delivery Systems* / methods
Needles*
Skin

Substances

Anti-Bacterial Agents

Abstract

MeSH terms

Substances

Grants and funding