New cyclic dipeptide discovered from deep-sea derived Aspergillus sp. HDN20-1401

Komal Anjum; Xiaofei Huang; Luning Zhou; Tianjiao Zhu; Qian Che; Guojian Zhang; Dehai Li

doi:10.1080/14786419.2023.2227754

New cyclic dipeptide discovered from deep-sea derived Aspergillus sp. HDN20-1401

Nat Prod Res. 2023 Jun 29:1-6. doi: 10.1080/14786419.2023.2227754. Online ahead of print.

Authors

Komal Anjum¹, Xiaofei Huang¹, Luning Zhou¹, Tianjiao Zhu¹, Qian Che¹, Guojian Zhang^{1

2

3}, Dehai Li^{1

2}

Affiliations

¹ Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
² Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
³ Marine Biomedical Research Institute of Qingdao, Qingdao, China.

PMID: 37384587
DOI: 10.1080/14786419.2023.2227754

Abstract

A new alkaloid named aspergilalkaloid A (1) with pyridoindole hydroxymethyl piperazine dione structure along with six known compounds 2-7 were isolated from deep-sea derived fungus Aspergillus sp. HDN20-1401. The structure including absolute configuration was elucidated by extensive NMR analyses, HRESIMS, ECD calculation, and theoretical NMR calculation with DP4+ analysis. All isolated compounds were tested for antimicrobial and anticancer activity. Aspergilalkaloid A (1) showed inhibitive activity against Bacillus cereus with MIC value of 12.5 μM and weak activity against MRCNS.

Keywords: Aspergillus sp; DP4+ analysis; antimicrobial activity; aspergilalkaloid A; medium amendment.