Noncoding RNA as an influential epigenetic modulator with promising roles in cancer therapeutics

Laboni Roy; Oishika Chatterjee; Debopriya Bose; Ananya Roy; Subhrangsu Chatterjee

doi:10.1016/j.drudis.2023.103690

Noncoding RNA as an influential epigenetic modulator with promising roles in cancer therapeutics

Drug Discov Today. 2023 Sep;28(9):103690. doi: 10.1016/j.drudis.2023.103690. Epub 2023 Jun 26.

Authors

Laboni Roy¹, Oishika Chatterjee¹, Debopriya Bose¹, Ananya Roy¹, Subhrangsu Chatterjee²

Affiliations

¹ Department of Biophysics, Bose Institute, Kolkata 700091, India.
² Department of Biophysics, Bose Institute, Kolkata 700091, India. Electronic address: subhrangsu@gmail.com.

PMID: 37379906
DOI: 10.1016/j.drudis.2023.103690

Abstract

The epigenetic landscape has an important role in cellular homeostasis and its deregulation leads to cancer. Noncoding (nc)RNA networks function as major regulators of cellular epigenetic hallmarks via regulation of vital processes, such as histone modification and DNA methylation. They are integral intracellular components affecting multiple oncogenic pathways. Thus, it is important to elucidate the effects of ncRNA networks on epigenetic programming that lead to the initiation and progression of cancer. In this review, we summarize the effects of epigenetic modification influenced by ncRNA networks and crosstalk between diverse classes of ncRNA, which could aid the development of patient-specific cancer therapeutics targeting ncRNAs, thereby altering cellular epigenetics.

Keywords: DNA methylation; cancer; histone modification; lncRNA; miRNA; ncRNA.

Publication types

Review

MeSH terms

DNA Methylation
Epigenesis, Genetic*
Humans
Neoplasms* / drug therapy
Neoplasms* / genetics
RNA, Untranslated / genetics

Substances

RNA, Untranslated