Oral microbiota in active and passive states of recurrent aphthous stomatitis: An analysis of case-control studies

Xuan Xiao; Zhaocheng Shi; Yuhan Song; Kaiyi Li; Shangfeng Liu; Zhifeng Song

doi:10.1016/j.archoralbio.2023.105751

Oral microbiota in active and passive states of recurrent aphthous stomatitis: An analysis of case-control studies

Arch Oral Biol. 2023 Sep:153:105751. doi: 10.1016/j.archoralbio.2023.105751. Epub 2023 Jun 17.

Authors

Xuan Xiao¹, Zhaocheng Shi¹, Yuhan Song¹, Kaiyi Li¹, Shangfeng Liu², Zhifeng Song³

Affiliations

¹ Department of Oral Mucosa, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China; Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China.
² Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China. Electronic address: Shangfeng_liu683@fudan.edu.cn.
³ Department of Oral Mucosa, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China; Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China. Electronic address: szf9110627@126.com.

PMID: 37379635
DOI: 10.1016/j.archoralbio.2023.105751

Abstract

Objective: This study was presented to reveal the most distinct microbial prevalence in recurrent aphthous stomatitis (RAS) lesions compared to healthy controls.

Design: The case-control studies were selected in electronic databases until Nov 2022 with key search terms, and the eligible publications were screened and analyzed by independent authors.

Results: A total of 14 studies were identified, which included 531 cases of active states of RAS (AS-RAS), 92 cases of passive states of RAS (PS-RAS) and 372 healthy controls. The most sample pattern was the mucosa swab performed in 8 of 14 studies, biopsies in 3 studies, followed by micro-brush, and saliva. A variety of bacteria in higher or lower abundance were observed in RAS lesions.

Conclusions: The etiopathogenesis of RAS may not be ascribed to a single pathogen. A possible explanation is that microbial interactions modify immune response or destroy the epithelial integrity, thus contributing to the development of the condition.

Keywords: 16 s rRNA sequencing; Microbiota; Mucosa swab; PCR; Recurrent aphthous stomatitis; Saliva.

MeSH terms

Case-Control Studies
Humans
Microbiota*
Recurrence
Stomatitis, Aphthous*

Supplementary concepts

Sutton disease 2