Genetic Associations with Coronavirus Susceptibility and Disease Severity

Fatima Barmania; Juanita Mellet; Megan A Holborn; Michael S Pepper

doi:10.1007/978-3-031-28012-2_6

Genetic Associations with Coronavirus Susceptibility and Disease Severity

Adv Exp Med Biol. 2023:1412:119-140. doi: 10.1007/978-3-031-28012-2_6.

Authors

Fatima Barmania¹, Juanita Mellet¹, Megan A Holborn¹, Michael S Pepper²

Affiliations

¹ Institute for Cellular and Molecular Medicine, Department of Immunology, SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
² Institute for Cellular and Molecular Medicine, Department of Immunology, SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. michael.pepper@up.ac.za.

PMID: 37378764
DOI: 10.1007/978-3-031-28012-2_6

Abstract

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) global public health emergency, and the disease it causes is highly variable in its clinical presentation. Host genetic factors are increasingly recognised as a determinant of infection susceptibility and disease severity. Several initiatives and groups have been established to analyse and review host genetic epidemiology associated with COVID-19 outcomes. Here, we review the genetic loci associated with COVID-19 susceptibility and severity focusing on the common variants identified in genome-wide association studies.

Keywords: Candidate gene; Covid-19; GWAS; Host genetics; SARS-CoV-2; Severity; Susceptibility; Variants.

Publication types

Review

MeSH terms

COVID-19* / epidemiology
COVID-19* / genetics
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Middle East Respiratory Syndrome Coronavirus*
Patient Acuity
SARS-CoV-2 / genetics