Association between psoriasis and peripheral artery occlusive disease: a population-based retrospective cohort study

Chao-Bin Yeh; Liang-Tsai Yeh; Shun-Fa Yang; Bo-Yuan Wang; Yu-Hsun Wang; Chi-Ho Chan

doi:10.3389/fcvm.2023.1136540

Association between psoriasis and peripheral artery occlusive disease: a population-based retrospective cohort study

Front Cardiovasc Med. 2023 Jun 12:10:1136540. doi: 10.3389/fcvm.2023.1136540. eCollection 2023.

Authors

Chao-Bin Yeh^#^{1

2

3}, Liang-Tsai Yeh^#^{4

5}, Shun-Fa Yang^{3

6}, Bo-Yuan Wang^{1

2

3}, Yu-Hsun Wang⁶, Chi-Ho Chan^{6

7}

Affiliations

¹ Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
² Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
³ Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
⁴ Department of Anesthesiology, Changhua Christian Hospital, Changhua, Taiwan.
⁵ Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
⁶ Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
⁷ Department of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.

^# Contributed equally.

Abstract

Introduction: Psoriasis (PSO) is a chronic skin condition that affects a variety of disorders, especially the cardiovascular system. This study investigated the association between PSO and peripheral arterial disease (PAOD).

Methods: A retrospective cohort study design was carried out between 2000 and 2018. The exposure subject was a newly diagnosed PSO. The diagnosis of PSO was never elaborated as a comparison subject. Balanced heterogeneity of the two groups was used by propensity score matching. The cumulative incidence of PAOD between the two groups was performed using Kaplan-Meier analysis. The Cox proportional hazard model was used to measure the risk of PAOD risk hazard ratio.

Results: After matching the 1: 1 propensity score, 15,696 subjects with PSO and the same number of subjects without the diagnosis of PSO were recruited. The PSO subject had a higher risk of PAOD than the non-PSO subject (adjusted HR = 1.25; 95% CI = 1.03-1.50). In the 40-64-year-old subgroup, the subject of PSO exhibited an increased risk of PAOD than the subject without PSO.

Conclusion: Psoriasis is associated with an increased risk of peripheral arterial disease and curative care is necessary to reduce the risk of PAOD..

Keywords: peripheral arterial occlusive diseases; propensity score matching; psoriasis; retrospective cohort study; risks.

Grants and funding

This study was partly based on data from the NHIRD provided by the NHI Administration, Ministry of Health and Welfare, and managed by the National Health Research Institutes. The interpretation and conclusions contained herein do not represent those of the NHI Administration, Ministry of Health and Welfare, or National Health Research Institutes. This study was funded by Chung Shan Medical University Hospital (CSH-2022-C-010 and CSH-2023-C-042).