A Case of Colchicine Toxicity Presenting With Euglycemic Diabetic Ketoacidosis

Sean D Delshad; Angela Kleiber

doi:10.7759/cureus.39063

A Case of Colchicine Toxicity Presenting With Euglycemic Diabetic Ketoacidosis

Cureus. 2023 May 15;15(5):e39063. doi: 10.7759/cureus.39063. eCollection 2023 May.

Authors

Sean D Delshad¹, Angela Kleiber¹

Affiliation

¹ Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, USA.

Abstract

Colchicine has a narrow therapeutic window and a high risk of toxicity when co-administered with CYP3A4 inhibitors and P-glycoprotein inhibitors. Colchicine toxicity is associated with various metabolic disturbances and can cause multiorgan failure and death. However, to our knowledge, there are no documented reports of colchicine toxicity initially presenting as euglycemic diabetic ketoacidosis (DKA). We present a case of colchicine toxicity with concomitant euglycemic DKA in a man with long-term colchicine use who was also prescribed clarithromycin and dapagliflozin.

Keywords: colchicine poisoning; diabetic keto acidosis; dka with normal blood glucose; internal medicine (general medicine); precipitating factors for euglycemic dka.

Publication types

Case Reports