CXCL8 and the peritoneal metastasis of ovarian and gastric cancer

Xuanrong Fu; Qimeng Wang; Hang Du; Huifang Hao

doi:10.3389/fimmu.2023.1159061

CXCL8 and the peritoneal metastasis of ovarian and gastric cancer

Front Immunol. 2023 Jun 12:14:1159061. doi: 10.3389/fimmu.2023.1159061. eCollection 2023.

Authors

Xuanrong Fu¹, Qimeng Wang¹, Hang Du¹, Huifang Hao¹

Affiliation

¹ School of Life Sciences, Inner Mongolia University, Hohhot, China.

Abstract

CXCL8 is the most representative chemokine produced autocrine or paracrine by tumor cells, endothelial cells and lymphocytes. It can play a key role in normal tissues and tumors by activating PI3K-Akt, PLC, JAK-STAT, and other signaling pathways after combining with CXCR1/2. The incidence of peritoneal metastasis in ovarian and gastric cancer is extremely high. The structure of the peritoneum and various peritoneal-related cells supports the peritoneal metastasis of cancers, which readily produces a poor prognosis, low 5-year survival rate, and the death of patients. Studies show that CXCL8 is excessively secreted in a variety of cancers. Thus, this paper will further elaborate on the mechanism of CXCL8 and the peritoneal metastasis of ovarian and gastric cancer to provide a theoretical basis for the proposal of new methods for the prevention, diagnosis, and treatment of cancer peritoneal metastasis.

Keywords: CXCL8; CXCR1/2; ovarian and gastric cancer peritoneal metastases; peritoneal; peritoneal metastases.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Endothelial Cells
Female
Humans
Peritoneal Neoplasms*
Peritoneum
Phosphatidylinositol 3-Kinases
Stomach Neoplasms*

Substances

Phosphatidylinositol 3-Kinases

Grants and funding

This work was supported by the Natural Sciences Foundation of China (NO.31860309,32160836), Science and Technology Major Project of Inner Mongolia Autonomous Region of China (No. 2020ZD15), Inner Mongolia Key Laboratory for Molecular Regulation of the Cell (NO. 2021PT0002).