Long non-coding RNAs in intracerebral hemorrhage

Chenyu Zhang; Ying Zhang; Qi Wang; Zhenwei Fang; Xinyi Xu; Mengnan Zhao; Ting Xu

doi:10.3389/fnmol.2023.1119275

Long non-coding RNAs in intracerebral hemorrhage

Front Mol Neurosci. 2023 Jun 12:16:1119275. doi: 10.3389/fnmol.2023.1119275. eCollection 2023.

Authors

Chenyu Zhang^{1

2}, Ying Zhang¹, Qi Wang¹, Zhenwei Fang¹, Xinyi Xu^{1

2}, Mengnan Zhao¹, Ting Xu^{1

2}

Affiliations

¹ Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, China.
² West China School of Pharmacy, Sichuan University, Chengdu, China.

Abstract

Intracerebral hemorrhage (ICH), a subtype of stroke, can lead to long-term disability and is one of the leading causes of death. Unfortunately, the effectiveness of pharmacological therapy for ICH is still uncertain. Long non-coding RNA (lncRNA) was defined as an RNA molecule that consists of more than 200 nt without translational activity. As a vital class of diverse molecules, lncRNAs are involved in developmental and pathological processes and have been attractive for decades. LncRNAs have also become potential targets for therapies, as they were massively identified and profiled. In particular, emerging evidence has revealed the critical role of lncRNAs in ICH while attempts were made to treat ICH via regulating lncRNAs. But the latest evidence remains to be summarized. Thus, in this review, we will summarize the recent advances in lncRNA in ICH, highlighting the regulatory role of lncRNAs and their potential as therapeutic targets.

Keywords: hemorrhagic stroke; intracerebral hemorrhage; long non-coding RNA; pathology; therapeutic target.

Publication types

Review