High urinary desmosine is associated with long-term mortality in patients with COPD

Changhwan Kim; Yousang Ko; Jae Seung Lee; Chin Kook Rhee; Jin Hwa Lee; Ji-Yong Moon; Seong Yong Lim; Kwang Ha Yoo; Joon Beom Seo; Yeon-Mok Oh; Sang-Do Lee; Yong Bum Park

doi:10.1183/23120541.00078-2023

High urinary desmosine is associated with long-term mortality in patients with COPD

ERJ Open Res. 2023 Jun 26;9(3):00078-2023. doi: 10.1183/23120541.00078-2023. eCollection 2023 May.

Authors

Changhwan Kim^{1

2

3}, Yousang Ko^{2

4

3}, Jae Seung Lee^{2

5}, Chin Kook Rhee^{2

6}, Jin Hwa Lee^{2

7}, Ji-Yong Moon^{2

8}, Seong Yong Lim^{2

9}, Kwang Ha Yoo^{2

10}, Joon Beom Seo^{2

11}, Yeon-Mok Oh^{2

5}, Sang-Do Lee^{2

5}, Yong Bum Park^{2

4}

Affiliations

¹ Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Republic of Korea.
² Clinical Research Center for Chronic Obstructive Airway Diseases, Seoul, Republic of Korea.
³ These authors contributed equally.
⁴ Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
⁵ Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
⁶ Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
⁷ Department of Internal Medicine, Ewha Womans University Seoul Hospital, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.
⁸ Division of Pulmonology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Republic of Korea.
⁹ Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
¹⁰ Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea.
¹¹ Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Abstract

COPD patients with high baseline urinary desmosines demonstrated significantly higher mortality than those with lower urinary desmosines. High urinary desmosine is independently associated with an increased risk of long-term mortality in COPD patients. https://bit.ly/4015xZ9.