The Recent Research Progress of NF-κB Signaling on the Proliferation, Migration, Invasion, Immune Escape and Drug Resistance of Glioblastoma

Pengfei Shi; Jie Xu; Hongjuan Cui

doi:10.3390/ijms241210337

The Recent Research Progress of NF-κB Signaling on the Proliferation, Migration, Invasion, Immune Escape and Drug Resistance of Glioblastoma

Int J Mol Sci. 2023 Jun 19;24(12):10337. doi: 10.3390/ijms241210337.

Authors

Pengfei Shi^{1

2}, Jie Xu^{1

2}, Hongjuan Cui^{1

2

3}

Affiliations

¹ Cancer Center, Medical Research Institute, Southwest University, Chongqing 400716, China.
² Jinfeng Laboratory, Chongqing 401329, China.
³ State Key Laboratory of Resource Insects, Southwest University, Chongqing 400716, China.

Abstract

Glioblastoma multiforme (GBM) is the most common and invasive primary central nervous system tumor in humans, accounting for approximately 45-50% of all primary brain tumors. How to conduct early diagnosis, targeted intervention, and prognostic evaluation of GBM, in order to improve the survival rate of glioblastoma patients, has always been an urgent clinical problem to be solved. Therefore, a deeper understanding of the molecular mechanisms underlying the occurrence and development of GBM is also needed. Like many other cancers, NF-κB signaling plays a crucial role in tumor growth and therapeutic resistance in GBM. However, the molecular mechanism underlying the high activity of NF-κB in GBM remains to be elucidated. This review aims to identify and summarize the NF-κB signaling involved in the recent pathogenesis of GBM, as well as basic therapy for GBM via NF-κB signaling.

Keywords: NF-κB; drug resistance; glioblastoma; immune escape; proliferation.

Publication types

Review

MeSH terms

Brain Neoplasms* / drug therapy
Brain Neoplasms* / pathology
Cell Line, Tumor
Cell Proliferation
Drug Resistance, Neoplasm*
Glioblastoma* / drug therapy
Glioblastoma* / pathology
Humans
NF-kappa B* / metabolism

Substances

NF-kappa B

Grants and funding

This research was supported by the Natural Science Foundation of Chongqing (cstc2022ycjh-bgzxm0145), the pilot program of Southwest University (SWU-XDZD22006).