The Effects of a High-Fat Diet on Inflammatory Bowel Disease

Yuan Dang; Chunxiang Ma; Kexin Chen; Yiding Chen; Mingshan Jiang; Kehan Hu; Lili Li; Zhen Zeng; Hu Zhang

doi:10.3390/biom13060905

The Effects of a High-Fat Diet on Inflammatory Bowel Disease

Biomolecules. 2023 May 30;13(6):905. doi: 10.3390/biom13060905.

Authors

Yuan Dang^{1

2

3}, Chunxiang Ma^{1

2

3}, Kexin Chen^{1

2

3}, Yiding Chen¹, Mingshan Jiang^{1

2

3}, Kehan Hu^{1

2

3}, Lili Li^{1

2

3}, Zhen Zeng^{1

2

3}, Hu Zhang^{1

2

3}

Affiliations

¹ Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China.
² Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu 610041, China.
³ Laboratory of Inflammatory Bowel Disease, Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.

Abstract

The interactions among diet, intestinal immunity, and microbiota are complex and play contradictory roles in inflammatory bowel disease (IBD). An increasing number of studies has shed light on this field. The intestinal immune balance is disrupted by a high-fat diet (HFD) in several ways, such as impairing the intestinal barrier, influencing immune cells, and altering the gut microbiota. In contrast, a rational diet is thought to maintain intestinal immunity by regulating gut microbiota. In this review, we emphasize the crucial contributions made by an HFD to the gut immune system and microbiota.

Keywords: high-fat diet; inflammatory bowel disease; intestinal barrier; intestinal microflora; pattern recognition receptor.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Diet, High-Fat / adverse effects
Gastrointestinal Microbiome*
Humans
Inflammatory Bowel Diseases* / etiology
Microbiota*

Grants and funding

This research was funded by the Provincial Scientific Research Fund of Science and Technology Department of Sichuan Province (No. 2021YFH0189). The work was also funded by the project for disciplines of excellence–Clinical Research Incubation Project, West China Hospital, Sichuan University (Grant Number: 2021HXFH065).