First Case of VIM-1-like-Producing Pseudomonas putida Bacteremia in an Oncohematological Pediatric Patient in Italy

Venere Cortazzo; Marilena Agosta; Stefania Gaspari; Gianluca Vrenna; Barbara Lucignano; Manuela Onori; Valentina Di Ruscio; Livia Mancinelli; Danielle Domo; Carlo Federico Perno; Paola Bernaschi

doi:10.3390/antibiotics12061033

First Case of VIM-1-like-Producing Pseudomonas putida Bacteremia in an Oncohematological Pediatric Patient in Italy

Antibiotics (Basel). 2023 Jun 9;12(6):1033. doi: 10.3390/antibiotics12061033.

Affiliations

¹ Microbiology and Diagnostic Immunology Unit, Department of Diagnostic and Laboratory Medicine, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
² Department of Hematology/Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
³ Faculty of Medicine and Surgery, Department of Experimental Medicine, Ph.D. Course in Microbiology, Immunology, Infectious Diseases and Transplants (MIMIT), University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

Abstract

Bacterial infections caused by multidrug-resistant (MDR) Gram-negatives are of great concern worldwide, as they are frequently associated with high mortality and morbidity rates. To date, two cases of VIM-2 metallo-β-lactamase (MBL)-producing Pseudomonas putida bacteremia have been ever reported in France and Spain between 2004 and 2010. Here, we present the first case of VIM-1-like-producing P. putida isolated in blood culture collected from an oncohematological pediatric patient admitted to Bambino Gesù Children's Hospital (IRCCS) in Rome, Italy.

Keywords: Pseudomonas putida; VIM-1-like; metallo-β-lactamases; multidrug-resistant; pediatric patient; polymicrobial bacteremia.

Publication types

Case Reports

Grants and funding

This research was supported by EU funding within the NextGenerationEU-MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases (Project no. PE00000007, INF-ACT) and by ANIA funding. This work was also supported by the Italian Ministry of Health with Current Research funds.