Emerging roles of ferroptosis-related miRNAs in tumor metastasis

Zhongyi Jiang; Jing Zhou; Junqi Deng; Luohong Li; Ruifeng Wang; Yingying Han; Junyu Zhou; Rui Tao; Lushan Peng; Dan Wang; Tao Huang; Yupei Yu; Zongjiang Zhou; Jinghe Li; Diabate Ousmane; Junpu Wang

doi:10.1038/s41420-023-01486-y

Emerging roles of ferroptosis-related miRNAs in tumor metastasis

Cell Death Discov. 2023 Jun 27;9(1):193. doi: 10.1038/s41420-023-01486-y.

Authors

Zhongyi Jiang^#^{1

2

3

4

5}, Jing Zhou^#^{1

2

3

4

5}, Junqi Deng^{1

2}, Luohong Li^{1

2}, Ruifeng Wang^{1

2}, Yingying Han^{1

2}, Junyu Zhou^{1

2}, Rui Tao^{1

2}, Lushan Peng^{1

2}, Dan Wang^{1

2}, Tao Huang^{1

2}, Yupei Yu^{1

2}, Zongjiang Zhou^{1

2}, Jinghe Li^{1

2}, Diabate Ousmane^{1

2}, Junpu Wang^{6

7

8

9

10}

Affiliations

¹ Department of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
² Department of Pathology, School of Basic Medicine, Central South University, Changsha City, Hunan Province, China.
³ Ultrapathology (Biomedical electron microscopy) Center, Department of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China.
⁴ Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁵ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
⁶ Department of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China. wang-jp2013@csu.edu.cn.
⁷ Department of Pathology, School of Basic Medicine, Central South University, Changsha City, Hunan Province, China. wang-jp2013@csu.edu.cn.
⁸ Ultrapathology (Biomedical electron microscopy) Center, Department of Pathology, Xiang-ya Hospital, Central South University, Changsha City, Hunan Province, China. wang-jp2013@csu.edu.cn.
⁹ Key Laboratory of Hunan Province in Neurodegenerative Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China. wang-jp2013@csu.edu.cn.
¹⁰ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. wang-jp2013@csu.edu.cn.

^# Contributed equally.

Abstract

Ferroptosis, a novel mode of cell death dependent on iron and reactive oxygen species, has been extensively explored during malignant tumors metastasis. Ferroptosis can interact with multiple components of the tumor microenvironment to regulate metastasis. These interactions generally include the following aspects: (1) Epithelial-mesenchymal transformation, which can help cancer cells increase their sensitivity to ferroptosis while they have multiple mechanisms to fight against it; (2) Disorder of iron metabolism in cancer stem cells which maintains their stem characteristics; (3) Polarization of M0 macrophages to M2. (4) The paradoxical effects of iron metabolism and CD8 + T cells induced by ferroptosis (5) Regulation of angiogenesis. In addition, ferroptosis can be regulated by miRNAs through the reprogramming of various intracellular metabolism processes, including the regulation of the glutathione- glutathione peroxidase 4 pathway, glutamic acid/cystine transport, iron metabolism, lipid metabolism, and oxidative stress. Therefore, there are many potential interactions between ferroptosis-related miRNAs and tumor metastasis, including interaction with cancer cells and immune cells, regulating cytokines, and angiogenesis. This review focuses on the role of ferroptosis-related miRNA in tumor metastasis, aiming to help readers understand their relationship and provide a new perspective on the potential treatment strategies of malignant tumors.

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Review

Abstract

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