Li-Fraumeni syndrome in the setting of re-occurring malignancies after 27 years of remission: a case report

Ahmed H Mousa; Abdullatif S Ibrahim; Abdelrahman Waleed Alsayed; Zain Z Albukhari; Ajfan Mogharbel; Asim M Alshanberi; Nezar Y Albar

doi:10.1097/MS9.0000000000000724

Li-Fraumeni syndrome in the setting of re-occurring malignancies after 27 years of remission: a case report

Ann Med Surg (Lond). 2023 Apr 27;85(6):3012-3016. doi: 10.1097/MS9.0000000000000724. eCollection 2023 Jun.

Authors

Ahmed H Mousa¹, Abdullatif S Ibrahim¹, Abdelrahman Waleed Alsayed¹, Zain Z Albukhari¹, Ajfan Mogharbel², Asim M Alshanberi^{1

3}, Nezar Y Albar⁴

Affiliations

¹ College of Medicine and Surgery, Batterjee Medical College, Jeddah, Saudi Arabia.
² Ibn Siena National College, Medicine and Surgery.
³ Department of Community Medicine and Pilgrims Health Care, Umm Al-Qura University, Makkah.
⁴ Dr. Samir Abbas Hospital, Jeddah, Saudi Arabia.

Abstract

Multiple primary tumors are defined as multiple simultaneous (within 6 months) or heterogeneous tumors.

Case presentation: Here, the authors present the case of a 58-year-old Saudi female patient with Li-Fraumeni syndrome who has multiple primary tumors.

Clinical discussion: The surgical cytoreduction or 'debulking' technique is the main treatment option started in individuals with High Grade Serous Ovarian CanceR. This surgical strategy aims to completely remove all disseminated tumor masses that are present in the patient's peritoneal cavity on a macroscopic level.

Conclusion: In conclusion, in our case, she has developed her ovarian cancer 27 years after her breast cancer got treated. This was already stage IIIB to stage IV. If it was not for her incidental discovery of her urinary bladder cancer, which is most likely is a long-term sequel of using cyclophosphamide 27 years ago.Multiple primary tumors are defined as multiple simultaneous (within 6 months) or heterogeneous tumors. Here, the authors present the case of a 58-year-old Saudi female patient with Li-Fraumeni syndrome who has multiple primary tumors. In conclusion, in our case, she has developed her ovarian cancer 27 years after her breast cancer got treated. This was already stage IIIB to stage IV. If it was not for her incidental discovery of her urinary bladder cancer, which is most likely is a long-term sequel of using cyclophosphamide 27 years ago.

Keywords: Li-Fraumeni syndrome; cancer; malignancies; oncology.