Investigation of the impacts of simple electrolytes and hydrotrope on the interaction of ceftriaxone sodium with cetylpyridinium chloride at numerous study temperatures

Md Nazrul Islam; Malik Abdul Rub; Maha Moteb Alotaibi; Md Tuhinur R Joy; Israt Jahan; Shamim Mahbub; Shahed Rana; Dileep Kumar; M Alfakeer; Abdullah M Asiri; Md Anamul Hoque; Shariff E Kabir

doi:10.1007/s11696-023-02856-7

Investigation of the impacts of simple electrolytes and hydrotrope on the interaction of ceftriaxone sodium with cetylpyridinium chloride at numerous study temperatures

Chem Zvesti. 2023 May 20:1-14. doi: 10.1007/s11696-023-02856-7. Online ahead of print.

Authors

Md Nazrul Islam¹, Malik Abdul Rub^{2

3}, Maha Moteb Alotaibi³, Md Tuhinur R Joy⁴, Israt Jahan⁴, Shamim Mahbub⁵, Shahed Rana¹, Dileep Kumar^{6

7}, M Alfakeer⁸, Abdullah M Asiri^{2

3}, Md Anamul Hoque¹, Shariff E Kabir^{1

9}

Affiliations

¹ Department of Chemistry, Jahangirnagar University, Savar, Dhaka, 1342 Bangladesh.
² Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 21589 Saudi Arabia.
³ Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, 21589 Saudi Arabia.
⁴ Department of Chemistry, Jashore University of Science and Technology, Jashore, 7408 Bangladesh.
⁵ Nuclear Safety, Security and Safeguards Division, Bangladesh Atomic Energy Regulatory Authority, Dhaka, 1207 Bangladesh.
⁶ Laboratory for Chemical Computation and Modeling, Institute for Computational Science and Artificial Intelligence, Van Lang University, Ho Chi Minh City, Vietnam.
⁷ Faculty of Applied Technology, School of Technology, Van Lang University, Ho Chi Minh City, Vietnam.
⁸ Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671 Saudi Arabia.
⁹ Department of Chemistry, Jagannath University, Dhaka, 1100 Bangladesh.

Abstract

Herein, interactions between cetylpyridinium chloride (CPC) and ceftriaxone sodium (CTS) were investigated applying conductivity technique. Impacts of the nature of additives (e.g. electrolytes or hydrotrope (HDT)), change of temperatures (from 298.15 to 323.15 K), and concentration variation of CTS/additives were assessed on the micellization of CPC + CTS mixture. The conductometric analysis of critical micelle concentration (CMC) with respect to the concentration reveals that the CMC values were increased with the increase in CTS concentration. In terms of using different mediums, CMC did not differ much with the increase in electrolyte salt (NaCl, Na₂SO₄) concentration, but increased significantly with the rise of HDT (NaBenz) amount. In the presence of electrolyte, CMC showed a gentle increment with temperature, while the HDT showed the opposite trend. Obtained result was further correlated with conventional thermodynamic relationship, where standard Gibb's free energy change $(Δ G_{m}^{o})$ , change of enthalpy $(Δ H_{m}^{o})$ , and change of entropy $(Δ S_{m}^{o}$ ) were utilized to investigate. The $Δ G_{m}^{o}$ values were negative for all the mixed systems studied indicating that the micellization process was spontaneous. Finally, the stability of micellization was studied by estimating the intrinsic enthalpy gain ( $Δ H_{m}^{o, *}$ ) and compensation temperature (T_c). Here, CPC + CTS mixed system showed more stability in Na₂SO₄ medium than the NaCl, while in NaBenz exhibited the lowest stability.

Keywords: Hydrotrope; Interaction forces; Molecular assembly; Surfactant system; Thermodynamics.

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