Exercise Rehabilitation and Chronic Respiratory Diseases: Effects, Mechanisms, and Therapeutic Benefits

Int J Chron Obstruct Pulmon Dis. 2023 Jun 19:18:1251-1266. doi: 10.2147/COPD.S408325. eCollection 2023.

Abstract

Chronic respiratory diseases (CRD), is a group of disorders, primarily chronic obstructive pulmonary disease and asthma, which are characterized by high prevalence and disability, recurrent acute exacerbations, and multiple comorbidities, resulting in exercise limitations and reduced health-related quality of life. Exercise training, an important tool in pulmonary rehabilitation, reduces adverse symptoms in patients by relieving respiratory limitations, increasing gas exchange, increasing central and peripheral hemodynamic forces, and enhancing skeletal muscle function. Aerobic, resistance, and high-intensity intermittent exercises, and other emerging forms such as aquatic exercise and Tai Chi effectively improve exercise capacity, physical fitness, and pulmonary function in patients with CRD. The underlying mechanisms include enhancement of the body's immune response, better control of the inflammatory response, and acceleration of the interaction between the vagus and sympathetic nerves to improve gas exchange. Here, we reviewed the new evidence of benefits and mechanisms of exercise intervention in the pulmonary rehabilitation of patients with chronic obstructive pulmonary disease, bronchial asthma, bronchiectasis, interstitial lung disease, and lung cancer.

Keywords: asthma; bronchiectasis; chronic obstructive pulmonary disease; chronic respiratory disease; exercise training; interstitial lung disease; lung cancer.

Publication types

  • Review

MeSH terms

  • Asthma* / diagnosis
  • Asthma* / therapy
  • Exercise Therapy
  • Exercise Tolerance
  • Humans
  • Lung
  • Pulmonary Disease, Chronic Obstructive* / diagnosis
  • Pulmonary Disease, Chronic Obstructive* / therapy
  • Quality of Life
  • Respiration Disorders*

Grants and funding

This work was supported by the National Natural Science Foundation of China [Grant No.32000831], the Shanghai Key Lab of Human Performance (Shanghai University of Sport) [Grant numbers 11DZ2261100], and the Shanghai Sailing Program (Fund number: 20YF1446500).