Mesoporous silica nanoparticles with dual-targeting agricultural sources for enhanced cancer treatment via tritherapy

Yu-Ya Huang; Zui-Harng Lee; Kai-Chi Chang; Zhi-Yuan Wu; Cheng-Chang Lee; Min-Hsuan Tsou; Hsiu-Mei Lin

doi:10.1039/d3ra02068a

Mesoporous silica nanoparticles with dual-targeting agricultural sources for enhanced cancer treatment via tritherapy

RSC Adv. 2023 Jun 23;13(28):19079-19090. doi: 10.1039/d3ra02068a. eCollection 2023 Jun 22.

Authors

Yu-Ya Huang¹, Zui-Harng Lee¹, Kai-Chi Chang², Zhi-Yuan Wu¹, Cheng-Chang Lee¹, Min-Hsuan Tsou¹, Hsiu-Mei Lin^{1

3

4}

Affiliations

¹ National Taiwan Ocean University, Department of Bioscience and Biotechnology No. 2, Beining Rd., Zhongzheng Dist. Keelung City 202 Taiwan Republic of China hmlin@mail.ntou.edu.tw +886-2-2462-2192 +886-2-2462-2192.
² National Taiwan Ocean University, Bachelor Degree Program in Marine Biotechenology Taiwan.
³ National Taiwan Ocean University, Center of Excellence for the Oceans Taiwan.
⁴ National Taiwan Ocean University, Center of Excellence for Ocean Engineering Taiwan.

Abstract

In this study, we introduced dual-targeting folic acid (FA) and hyaluronic acid (HA) modified on the surface of rice husk mesoporous silica nanoparticles (rMSNs). The rMSNs were employed as a drug delivery system loaded with camptothecin (CPT) as a model drug, Eu³⁺ ions as a photosensitizer for photodynamic therapy (PDT), bismuth (Bi) for photothermal therapy (PTT), and Gd³⁺ ions for magnetic resonance imaging (MRI) to develop novel nanoparticles, rMSN-EuGd-Bi@CPT-HA-FA, with dual-targeted function and triple therapy for cancer treatment. The results of the cell cytotoxicity experiment showed that the A549 cancer cells had a survival rate of approximately 35% when treated with 200 μg mL^-1 of rMSN-EuGd-Bi@CPT-HA-FA under 808 nm irradiation for 15 min. The dual-targeted function and synergistic treatment of CPT, PTT, and PDT were also responsible for the 20% survival rate of the A549 cancer cells treated with 200 μg mL^-1 of rMSN-EuGd-Bi@CPT-HA-FA under 808 nm irradiation for 30 min. The results showed that rMSN-EuGd-Bi@CPT-HA-FA can effectively combine chemotherapy (through CPT), PDT, and PTT for cancer treatment.