Antibacterial Mesoporous Silica Granules Containing a Stable N-Halamine Moiety

Yuqing Shi; Haidong Xu; Yijing He; Xuan Tang; Hongru Tian; Jie Liang

doi:10.1021/acsomega.2c04079

Antibacterial Mesoporous Silica Granules Containing a Stable N-Halamine Moiety

ACS Omega. 2023 Jun 5;8(24):21410-21417. doi: 10.1021/acsomega.2c04079. eCollection 2023 Jun 20.

Authors

Yuqing Shi¹, Haidong Xu¹, Yijing He¹, Xuan Tang¹, Hongru Tian¹, Jie Liang¹

Affiliation

¹ The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai200234, P. R. China.

Abstract

High-efficacy and regenerable antimicrobial silica granules were prepared via oxa-Michael addition between poly(vinyl alcohol) (PVA) and methylene-bis-acrylamide (MBA) under the catalysis of sodium carbonate in an aqueous solution. Diluted water glass was added, and the solution pH was adjusted to about 7 to precipitate PVA-MBA modified mesoporous silica (PVA-MBA@SiO₂) granules. N-Halamine-grafted silica (PVA-MBA-Cl@SiO₂) granules were achieved by adding diluted sodium hypochlorite solution. It was found that a BET surface area of about 380 m² g^-1 for PVA-MBA@SiO₂ granules and a Cl⁺% of about 3.80% for PVA-MBA-Cl@SiO₂ granules could be achieved under optimized preparation conditions. Antimicrobial tests showed that the as-prepared antimicrobial silica granules were capable of about a 6-log inactivation of Staphylococcus aureus and Escherichia coli O157:H7 within 10 min of contact. Furthermore, the as-prepared antimicrobial silica granules can be recycled many times due to the excellent regenerability of their N-halamine functional groups and can be saved for a long time. With the above-mentioned advantages, the granules have potential applications in water disinfection.