Recommendations for the measurement of sexual steroids in clinical practice. A position statement of SEQCML/SEEN/SEEP
Adv Lab Med. 2023 Mar 9;4(1):52-69.
doi: 10.1515/almed-2023-0020.
eCollection 2023 Apr.
[Article in
English,
Spanish]
Affiliations
- 1 Servicio de Bioquímica y Genética Molecular, Hospital Clínic, IDIBAPS, CIBEREHD Universidad de Barcelona, Barcelona, Spain.
- 2 Servicio de Bioquímica, Laboratoris Clínics, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
- 3 Servicio de Bioquímica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
- 4 Servicio de Endocrinología y Nutrición, Hospital Ramón y Cajal, Universidad de Alcalá, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS y CIBER Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Madrid, Spain.
- 5 Departamento de Pediatría y Endocrinología Pediátrica, Hospital Infantil Universitario Niño Jesús, Universidad Autonoma de Madrid, CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain.
- 6 Servicio de Endocrinología y Nutrición, Hospital Universitari Dexeus, Barcelona, Spain.
- 7 Servicio de Endocrinología y Nutrición, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Abstract
The proper clinical approach to a wide range of disorders relies on the availability of accurate, reproducible laboratory results for sexual steroids measured using methods with a high specificity and sensitivity. The chemiluminescent immunoassays currently available have analytical limitations with significant clinical implications. This position statement reviews the current limitations of laboratory techniques for the measurement of estradiol and testosterone and their impact on diverse clinical scenarios. A set of recommendations are provided to incorporate steroid hormone analysis by mass spectrometry in national health systems. International societies have recommended this methodology for a decade.
Keywords:
estradiol; immunoassay; mass spectrometry; sexual steroids; testosterone.
© 2023 the author(s), published by De Gruyter, Berlin/Boston.