Stem cell-derived exosome versus stem cell therapy

Nat Rev Bioeng. 2023 Apr 12:1-2. doi: 10.1038/s44222-023-00064-2. Online ahead of print.

Abstract

Stem cell therapies are being explored for the treatment of various diseases, including haematological disease, immune disease, neurodegenerative disease, and tissue injuries. Alternatively, stem cell-derived exosomes may provide similar clinical benefits without the biosafety concerns associated with the transplantation of living cells. However, large-scale manufacturing and purification, batch-to-batch variation, and analysis of the complex cargos of exosomes will need to be addressed to enable their clinical translation.

Keywords: Regenerative medicine; Stem-cell biotechnology; Stem-cell research; Tissue engineering.