Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field

Hao Du; Jian Xia; Lei Huang; Lan Zheng; Wenping Gu; Fang Yi

doi:10.3389/fnagi.2023.1190869

Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field

Front Aging Neurosci. 2023 Jun 8:15:1190869. doi: 10.3389/fnagi.2023.1190869. eCollection 2023.

Authors

Hao Du¹, Jian Xia^{1

2

3}, Lei Huang⁴, Lan Zheng¹, Wenping Gu^{1

2

3}, Fang Yi^{3

5}

Affiliations

¹ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Clinical Research Center for Cerebrovascular Disease of Hunan Province, Central South University, Changsha, Hunan, China.
³ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ Department of Rehabilitation, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China.
⁵ Department of Geriatric Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Abstract

Insulin-like growth factor-1 (IGF-1) is an active polypeptide protein that closely resembles the structural sequence of insulin and is involved in a variety of metabolic processes in the body. Decreased IGF-1 circulation levels are associated with an increased risk of stroke and a poorer prognosis, but the relationship with cerebral small vessel disease (cSVD) is unclear. Some studies found that the level of IGF-1 in patients with cSVD was significantly reduced, but the clinical significance and underlying mechanisms are unknown. This article reviews the correlation between IGF-1 and cerebrovascular disease and explores the potential relationship and mechanism between IGF-1 and cSVD.

Keywords: blood–brain barrier; cerebral small vessel disease; insulin-like growth factor-1; microvascular rarefaction; neurovascular unit.

Publication types

Review