TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ

Autophagy. 2023 Oct;19(10):2752-2768. doi: 10.1080/15548627.2023.2229659. Epub 2023 Jul 4.

Abstract

Aβ: amyloid β; AD: Alzheimer disease; AMPK: 5' adenosine monophosphate-activated protein kinase; CTSB: cathepsin B; CTSD: cathepsin D; DM: diabetes mellitus; ESCRT: endosomal sorting complex required for transport; FBXO27: F-box protein 27; iPSC-NDs: induced pluripotent stem cell-derived neuronal differentiated cells; LAMP1: lysosomal-associated membrane protein 1; LMP: lysosomal membrane permeabilization; LRSAM1: leucine rich repeat and sterile alpha motif containing 1; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MTORC1: mechanistic target of rapamycin kinase complex 1; p-MAPT/tau: phosphorylated microtubule associated protein tau; ROS: reactive oxygen species; STZ: streptozotocin; TFE3: transcription factor E3; TFEB: transcription factor EB; TRIM16: tripartite motif containing 16; UBE2QL1: ubiquitin conjugating enzyme E2 Q family like 1; VCP: valosin containing protein.

Keywords: Amyloid β; TFEB; TRIM16; autophagy; diabetes; hippocampal neuron.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Peptides / metabolism
  • Autophagy*
  • Glucose / metabolism
  • Lysosomes / metabolism
  • Macroautophagy*
  • Neurons / metabolism

Substances

  • Amyloid beta-Peptides
  • Glucose

Grants and funding

The author(s) reported this wok was funded by National R&D Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (RS-2023-00208475)