FSP1: a key regulator of ferroptosis

Wentao Li; Lin Liang; Siyi Liu; Hong Yi; Yanhong Zhou

doi:10.1016/j.molmed.2023.05.013

FSP1: a key regulator of ferroptosis

Trends Mol Med. 2023 Sep;29(9):753-764. doi: 10.1016/j.molmed.2023.05.013. Epub 2023 Jun 23.

Authors

Wentao Li¹, Lin Liang², Siyi Liu², Hong Yi³, Yanhong Zhou⁴

Affiliations

¹ Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Clinical Research Center of Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China; Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410011, China.
² Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410011, China.
³ Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Clinical Research Center of Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China. Electronic address: yihong68@csu.edu.cn.
⁴ Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Clinical Research Center of Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China; Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410011, China. Electronic address: zhouyanhong@csu.edu.cn.

PMID: 37357101
DOI: 10.1016/j.molmed.2023.05.013

Abstract

Ferroptosis suppressor protein 1 (FSP1) is one of the main regulatory molecules of ferroptosis. FSP1 functions through the FSP1-coenzyme Q10 (CoQ10)-NAD(P)H axis and the vitamin K redox cycle. FSP1 is regulated by upstream factors, including transcription factors and noncoding RNA (ncRNA), and is subject to epigenetic modifications, which affect the progress of FSP1-related diseases. FSP1 is closely associated with the poor prognosis of malignant tumors and plays an important role in disease treatment. This review aims to provide a comprehensive understanding of the role of FSP1 in ferroptosis regulation by summarizing regulatory pathways, possible mechanisms involving FSP1, and the relationship between FSP1 and disease prognosis and treatment.

Keywords: FSP1; epigenetic modification; ferroptosis; noncoding RNA; regulation mechanism.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Epigenesis, Genetic
Ferroptosis* / genetics
Humans
NAD
Transcription Factors
Vitamin K

Substances

NAD
Transcription Factors
Vitamin K