Drug-induced Capillary Leak Syndrome

J Assoc Physicians India. 2022 Oct;70(10):11-12. doi: 10.5005/japi-11001-0106.

Abstract

Capillary leak syndrome is a disease with a high mortality rate. Its signs and symptoms are nonspecific. Generalized edema, hypotension, hypoproteinemia, and hemoconcentration are the characteristics of capillary leak syndrome. Here we report three cases of capillary leak syndrome developed after being treated with gemcitabine and paclitaxel. Immediate treatment with corticosteroids may be life-saving.

MeSH terms

  • Capillary Leak Syndrome* / chemically induced
  • Capillary Leak Syndrome* / diagnosis
  • Capillary Leak Syndrome* / therapy
  • Edema / chemically induced
  • Gemcitabine
  • Humans
  • Hypotension*
  • Paclitaxel / adverse effects

Substances

  • Gemcitabine
  • Paclitaxel