Left Ventricular Function and Dimensions Are Altered Early in Infants Developing Brain Injury in the Setting of Neonatal Encephalopathy

J Pediatr. 2023 Oct:261:113585. doi: 10.1016/j.jpeds.2023.113585. Epub 2023 Jun 23.

Abstract

We evaluated the association between left cardiac 3-dimensional echocardiographic parameters and brain injury in a single-center prospective study of neonates with neonatal encephalopathy. On day 2 of life, neonates with brain injury had greater left ventricle end-diastolic and stroke volume but also greater peak global circumferential strain detected by 3-dimensional echocardiogram.

Keywords: 3D echocardiography; left ventricular function and dimensions; neonatal encephalopathy; speckle tracking echocardiography; therapeutic hypothermia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Injuries* / complications
  • Brain Injuries* / diagnostic imaging
  • Echocardiography / methods
  • Echocardiography, Three-Dimensional* / methods
  • Heart Ventricles / diagnostic imaging
  • Humans
  • Infant
  • Infant, Newborn
  • Prospective Studies
  • Stroke Volume
  • Ventricular Dysfunction, Left* / diagnostic imaging
  • Ventricular Function, Left

Grants and funding