Interaction between ultrasound-modified pectin and icaritin

Yipeng Chen; Yueming Jiang; Lingrong Wen; Bao Yang

doi:10.1016/j.foodchem.2023.136618

Interaction between ultrasound-modified pectin and icaritin

Food Chem. 2023 Nov 15:426:136618. doi: 10.1016/j.foodchem.2023.136618. Epub 2023 Jun 17.

Authors

Yipeng Chen¹, Yueming Jiang¹, Lingrong Wen², Bao Yang³

Affiliations

¹ State Key Laboratory of Plant Diversity and Prominent Crops, Guangdong Provincial Key Laboratory of Applied Botany, Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; South China National Botanical Garden, Guangzhou 510650, China; University of Chinese Academy of Sciences, Beijing 100049, China.
² State Key Laboratory of Plant Diversity and Prominent Crops, Guangdong Provincial Key Laboratory of Applied Botany, Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; South China National Botanical Garden, Guangzhou 510650, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: wenlingrong@scbg.ac.cn.
³ State Key Laboratory of Plant Diversity and Prominent Crops, Guangdong Provincial Key Laboratory of Applied Botany, Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; South China National Botanical Garden, Guangzhou 510650, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: yangbao@scbg.ac.cn.

PMID: 37354572
DOI: 10.1016/j.foodchem.2023.136618

Abstract

Pectin can improve the bioaccessibility of icaritin as a nanocarrier, and ultrasound can modify the pectin structure. However, the interaction between ultrasound-modified pectin (UMP) and icaritin remains unclearly. In this work, the effects of UMP on the physiochemical properties of icaritin/pectin micelles (IPMs) were investigated. The IPMs prepared with UMP (UMP-IPMs) showed lower encapsulation efficiencies and loading capacities, comparing with native IPMs. UMP-IPMs had smaller particle sizes (325-399 nm) than native IPMs (551 nm). The Mw, viscosity, G' and G" of pectin were determined. NMR spectra indicated that the repeating unit in pectins remained consistently before and after ultrasound treatment, and 7-OH of icaritin was involved in hydrogen bond formation with pectin. The larger chemical shift movement of 6-H and 7-OH for U3-IPMs than P0-IPMs suggested that stronger hydrogen bond interaction between icaritin and pectin. UMP-IPMs exhibited stronger anti-proliferation activities against HepG2 cells than native IPMs.

Keywords: Antiproliferative activity; Encapsulation efficiency; Flavonoid; Loading capacity; Microstructure; NMR.

MeSH terms

Flavonoids*
Micelles
Particle Size
Pectins* / chemistry
Viscosity

Substances

icaritin
Pectins
Flavonoids
Micelles