Shaping the cerebral cortex by cellular crosstalk

Julie Stoufflet; Sylvia Tielens; Laurent Nguyen

doi:10.1016/j.cell.2023.05.040

Shaping the cerebral cortex by cellular crosstalk

Cell. 2023 Jun 22;186(13):2733-2747. doi: 10.1016/j.cell.2023.05.040.

Authors

Julie Stoufflet¹, Sylvia Tielens¹, Laurent Nguyen²

Affiliations

¹ Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells and GIGA-Neurosciences, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, CHU Sart Tilman, Liège 4000, Belgium.
² Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells and GIGA-Neurosciences, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, CHU Sart Tilman, Liège 4000, Belgium; Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Wavres, Belgium. Electronic address: lnguyen@uliege.be.

PMID: 37352835
DOI: 10.1016/j.cell.2023.05.040

Abstract

The cerebral cortex is the brain's outermost layer. It is responsible for processing motor and sensory information that support high-level cognitive abilities and shape personality. Its development and functional organization strongly rely on cell communication that is established via an intricate system of diffusible signals and physical contacts during development. Interfering with this cellular crosstalk can cause neurodevelopmental disorders. Here, we review how crosstalk between migrating cells and their environment influences cerebral cortex development, ranging from neurogenesis to synaptogenesis and assembly of cortical circuits.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Communication
Cerebral Cortex*
Cognition
Neurogenesis*