Expanding the Substrate Scope of Acyltransferase LovD9 for the Biosynthesis of Statin Analogues

Guillermo García-Marquina; Reyes Núñez-Franco; Daniel Grajales-Hernández; Gonzalo Jiménez-Osés; Fernando López-Gallego

doi:10.1002/chem.202301869

Expanding the Substrate Scope of Acyltransferase LovD9 for the Biosynthesis of Statin Analogues

Chemistry. 2023 Jul 26;29(42):e202301869. doi: 10.1002/chem.202301869. Epub 2023 Jun 23.

Authors

Guillermo García-Marquina^{1

2}, Reyes Núñez-Franco³, Daniel Grajales-Hernández², Gonzalo Jiménez-Osés^{3

4}, Fernando López-Gallego^{2

4}

Affiliations

¹ Departamento de Química, Centro de Investigación en Síntesis Química, Universidad de La Rioja, 26006, Logroño, Spain.
² Center for cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramón, 182, 20014, Donostia-San Sebastián, Spain.
³ Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160, Derio, Spain.
⁴ lkerbasque, Basque Foundation for Science, 48009, Bilbao, Spain.

PMID: 37350118
DOI: 10.1002/chem.202301869

Abstract

Invited for the cover of this issue are the groups of Gonzalo Jiménez-Osés and Fernando López-Gallego at CIC bioGUNE and CIC biomaGUNE, respectively. The image depicts the substrate scope of an engineered acyl transferases for the synthesis of statin derivatives. Read the full text of the article at 10.1002/chem.202300911.

MeSH terms

Acyltransferases
Hydroxymethylglutaryl-CoA Reductase Inhibitors*

Substances

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Acyltransferases