Oncogenic alterations of metabolism associated with resistance to chemotherapy

Fahimeh Ghasemi; Tahereh Farkhondeh; Saeed Samarghandian; Alireza Ghasempour; Mehdi Shakibaie

doi:10.2174/1566524023666230622104625

Oncogenic alterations of metabolism associated with resistance to chemotherapy

Curr Mol Med. 2023 Jun 22. doi: 10.2174/1566524023666230622104625. Online ahead of print.

Authors

Fahimeh Ghasemi^{1

2}, Tahereh Farkhondeh³, Saeed Samarghandian⁴, Alireza Ghasempour⁵, Mehdi Shakibaie^{1

6}

Affiliations

¹ Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
² Department of Medical Biotechnology, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
³ Department of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.
⁴ Healthy Ageing Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
⁵ Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
⁶ Department of Pharmaceutics and Nanotechnology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.

PMID: 37350008
DOI: 10.2174/1566524023666230622104625

Abstract

Metabolic reprogramming in cancer cells is a strategy to meet high proliferation rates, invasion, and metastasis. Also, several researchers indicated that the cellular metabolism changed during the resistance to chemotherapy. Since glycolytic enzymes play a prominent role in these alterations, the ability to reduce resistance to chemotherapy drugs is promising for cancer patients. Oscillating gene expression of these enzymes was involved in the proliferation, invasion, and metastasis of cancer cells. This review discussed the roles of some glycolytic enzymes associated with cancer progression and resistance to chemotherapy in the various cancer types.

Keywords: aldolase; chemotherapy resistance; enolase; glyceraldehyde 3-phosphate dehydrogenase; hexokinase; lactate dehydrogenase; phosphofructokinase; phosphoglycerate kinase; pyruvate kinase.