Non-motor symptoms in amyotrophic lateral sclerosis: lessons from Parkinson's disease

Ali Shojaie; Silvia Rota; Ahmad Al Khleifat; K Ray Chaudhuri; Ammar Al-Chalabi

doi:10.1080/21678421.2023.2220748

Non-motor symptoms in amyotrophic lateral sclerosis: lessons from Parkinson's disease

Amyotroph Lateral Scler Frontotemporal Degener. 2023 Jun 22:1-10. doi: 10.1080/21678421.2023.2220748. Online ahead of print.

Authors

Ali Shojaie¹, Silvia Rota^{1

2

3}, Ahmad Al Khleifat¹, K Ray Chaudhuri^{1

2

4

5}, Ammar Al-Chalabi^{1

4

5}

Affiliations

¹ Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
² Parkinson's Foundation Centre of Excellence, King's College Hospital, London, UK.
³ Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
⁴ National Institute for Health Research Biomedical Research Centre and Dementia Unit at South London and Maudsley NHS Foundation Trust and King's College London, London, UK, and.
⁵ Department of Neurology, King's College Hospital, London, UK.

PMID: 37349906
DOI: 10.1080/21678421.2023.2220748

Abstract

Amyotrophic lateral sclerosis and Parkinson's disease are neurodegenerative diseases of the motor system which are now recognized also to affect non-motor pathways. Non-motor symptoms have been acknowledged as important determinants of quality of life in Parkinson's disease, and there is increasing interest in understanding the extent and role of non-motor symptoms in amyotrophic lateral sclerosis. We therefore reviewed what is known about non-motor symptoms in amyotrophic lateral sclerosis, using lessons from Parkinson's disease.

Keywords: ALS; Amyotrophic lateral sclerosis; PD; Parkinson’s disease; non-motor symptoms; personalized medicine; quality of life.

Publication types

Review