Surgical Research Progress of Sentinel Lymph Node Biopsy in Melanoma

J Invest Surg. 2023 Dec;36(1):2225087. doi: 10.1080/08941939.2023.2225087.

Abstract

Malignant melanoma is a highly aggressive tumor, and lymph node metastasis significantly impacts the prognosis and treatment of this condition. Sentinel node biopsy, as a less invasive alternative to traditional dissection, offers convenience, safety, and improved efficiency in assessing local lymph node status. It provides valuable staging information and aids in determining appropriate follow-up treatment. The evolution and enhancement of technical and conceptual aspects associated with sentinel node biopsy have transformed the management of malignant melanoma. Notably, several large multicenter trials have challenged the necessity of complete lymph node dissection, leading to a paradigm shift. While some controversy remains, the standard of care for melanoma is progressing toward a consensus.

Keywords: Melanoma; Plastic surgery; biopsy; cancer; sentinel lymph node; staging; surgical research progress; surgical technique.

Publication types

  • Review

MeSH terms

  • Humans
  • Lymph Node Excision / adverse effects
  • Lymph Nodes / pathology
  • Melanoma* / diagnosis
  • Melanoma* / surgery
  • Melanoma, Cutaneous Malignant
  • Sentinel Lymph Node Biopsy
  • Skin Neoplasms* / diagnosis
  • Skin Neoplasms* / pathology
  • Skin Neoplasms* / surgery